In Schweinitz' time, the first responsibility of a botanist was to compile a flora of his geographic environment. As Schweinitz moved around a great deal in his work with the Moravian Church, unusual opportunities arose. A scanning of his titles gives a summary of his travels around Europe and in America.

There is mention in print that Lewis David von Schweinitz worked on a flora of Nazareth when he was in attendance at the Moravian school in that town in Pennsylvania. In his library was preserved a flora of that area with an appendix. However, the original list was done by Samuel Kramsch, von Schweinitz' teacher and the index and supplement were written by Denke. There is no evidence in publications or manuscripts that Schweinitz ever wrote such a flora.